Curiosity for machine agents has been a focus of lively research activity. The study of human and animal curiosity, particularly specific curiosity, has unearthed several properties that would offer important benefits for machine learners, but that have not yet been well-explored in machine intelligence. In this work, we conduct a comprehensive, multidisciplinary survey of the field of animal and machine curiosity. As a principal contribution of this work, we use this survey as a foundation to introduce and define what we consider to be five of the most important properties of specific curiosity: 1) directedness towards inostensible referents, 2) cessation when satisfied, 3) voluntary exposure, 4) transience, and 5) coherent long-term learning. As a second main contribution of this work, we show how these properties may be implemented together in a proof-of-concept reinforcement learning agent: we demonstrate how the properties manifest in the behaviour of this agent in a simple non-episodic grid-world environment that includes curiosity-inducing locations and induced targets of curiosity. As we would hope, our example of a computational specific curiosity agent exhibits short-term directed behaviour while updating long-term preferences to adaptively seek out curiosity-inducing situations. This work, therefore, presents a landmark synthesis and translation of specific curiosity to the domain of machine learning and reinforcement learning and provides a novel view into how specific curiosity operates and in the future might be integrated into the behaviour of goal-seeking, decision-making computational agents in complex environments.

在计算加强学习中，越来越多的作品试图通过预测未来的感觉来构建代理人对世界的看法。关于环境观察的预测用作额外的输入功能，以实现更好的目标指导决策。这项工作中的一个公开挑战是从代理商可能做出的许多预测中决定哪些预测可能最能支持决策。在连续学习问题中，这一挑战尤其明显，在这种问题上，单一的经验可以为单一的代理使用。作为主要贡献，我们介绍了一个元梯度下降过程，代理商通过该过程学习1）要做出的预测，2）其所选预测的估计值； 3）如何使用这些估计来生成最大化未来奖励的政策 - - 全部在一个持续学习的过程中。在本手稿中，我们将表达为一般价值函数的预测考虑：对未来信号积累的时间扩展估计。我们证明，通过与环境的互动，代理可以独立选择解决部分观察性的预测，从而产生类似于专业指定的GVF的性能。通过学习，而不是手动指定这些预测，我们使代理商能够以自我监督的方式确定有用的预测，从而迈向真正的自主系统。

在计算强化学习中，越来越多的工作体验旨在通过关于未来感觉的预测来表达世界的代理人模型。在本手稿中，我们专注于以一般值函数表示的预测：时间延长了未来信号累积的估计。一个挑战是从无数的许多预测中确定了代理人可能会产生哪些可能支持决策的预测。在这项工作中，我们贡献了一个元梯度下降方法，代理可以直接指定它学习的预测，而独立于设计者指令。为此，我们介绍了适合这项调查的部分可观察的域名。然后，我们演示通过与环境的交互，代理可以独立地选择解决部分可观察性的预测，从而导致类似于专业选择的值函数的性能。通过学习，而不是手动指定这些预测，我们使代理能够以自我监督的方式识别有用的预测，从而迈向真正自治系统。

Machine learning models are typically evaluated by computing similarity with reference annotations and trained by maximizing similarity with such. Especially in the bio-medical domain, annotations are subjective and suffer from low inter- and intra-rater reliability. Since annotations only reflect the annotation entity's interpretation of the real world, this can lead to sub-optimal predictions even though the model achieves high similarity scores. Here, the theoretical concept of Peak Ground Truth (PGT) is introduced. PGT marks the point beyond which an increase in similarity with the reference annotation stops translating to better Real World Model Performance (RWMP). Additionally, a quantitative technique to approximate PGT by computing inter- and intra-rater reliability is proposed. Finally, three categories of PGT-aware strategies to evaluate and improve model performance are reviewed.

Quaternion valued neural networks experienced rising popularity and interest from researchers in the last years, whereby the derivatives with respect to quaternions needed for optimization are calculated as the sum of the partial derivatives with respect to the real and imaginary parts. However, we can show that product- and chain-rule does not hold with this approach. We solve this by employing the GHRCalculus and derive quaternion backpropagation based on this. Furthermore, we experimentally prove the functionality of the derived quaternion backpropagation.

Neuromorphic systems require user-friendly software to support the design and optimization of experiments. In this work, we address this need by presenting our development of a machine learning-based modeling framework for the BrainScaleS-2 neuromorphic system. This work represents an improvement over previous efforts, which either focused on the matrix-multiplication mode of BrainScaleS-2 or lacked full automation. Our framework, called hxtorch.snn, enables the hardware-in-the-loop training of spiking neural networks within PyTorch, including support for auto differentiation in a fully-automated hardware experiment workflow. In addition, hxtorch.snn facilitates seamless transitions between emulating on hardware and simulating in software. We demonstrate the capabilities of hxtorch.snn on a classification task using the Yin-Yang dataset employing a gradient-based approach with surrogate gradients and densely sampled membrane observations from the BrainScaleS-2 hardware system.

Osteoarthritis (OA) is the most prevalent chronic joint disease worldwide, where knee OA takes more than 80% of commonly affected joints. Knee OA is not a curable disease yet, and it affects large columns of patients, making it costly to patients and healthcare systems. Etiology, diagnosis, and treatment of knee OA might be argued by variability in its clinical and physical manifestations. Although knee OA carries a list of well-known terminology aiming to standardize the nomenclature of the diagnosis, prognosis, treatment, and clinical outcomes of the chronic joint disease, in practice there is a wide range of terminology associated with knee OA across different data sources, including but not limited to biomedical literature, clinical notes, healthcare literacy, and health-related social media. Among these data sources, the scientific articles published in the biomedical literature usually make a principled pipeline to study disease. Rapid yet, accurate text mining on large-scale scientific literature may discover novel knowledge and terminology to better understand knee OA and to improve the quality of knee OA diagnosis, prevention, and treatment. The present works aim to utilize artificial neural network strategies to automatically extract vocabularies associated with knee OA diseases. Our finding indicates the feasibility of developing word embedding neural networks for autonomous keyword extraction and abstraction of knee OA.

Data-centric artificial intelligence (data-centric AI) represents an emerging paradigm emphasizing that the systematic design and engineering of data is essential for building effective and efficient AI-based systems. The objective of this article is to introduce practitioners and researchers from the field of Information Systems (IS) to data-centric AI. We define relevant terms, provide key characteristics to contrast the data-centric paradigm to the model-centric one, and introduce a framework for data-centric AI. We distinguish data-centric AI from related concepts and discuss its longer-term implications for the IS community.

Many real-world reinforcement learning tasks require control of complex dynamical systems that involve both costly data acquisition processes and large state spaces. In cases where the transition dynamics can be readily evaluated at specified states (e.g., via a simulator), agents can operate in what is often referred to as planning with a \emph{generative model}. We propose the AE-LSVI algorithm for best-policy identification, a novel variant of the kernelized least-squares value iteration (LSVI) algorithm that combines optimism with pessimism for active exploration (AE). AE-LSVI provably identifies a near-optimal policy \emph{uniformly} over an entire state space and achieves polynomial sample complexity guarantees that are independent of the number of states. When specialized to the recently introduced offline contextual Bayesian optimization setting, our algorithm achieves improved sample complexity bounds. Experimentally, we demonstrate that AE-LSVI outperforms other RL algorithms in a variety of environments when robustness to the initial state is required.

Multimodal deep learning has been used to predict clinical endpoints and diagnoses from clinical routine data. However, these models suffer from scaling issues: they have to learn pairwise interactions between each piece of information in each data type, thereby escalating model complexity beyond manageable scales. This has so far precluded a widespread use of multimodal deep learning. Here, we present a new technical approach of "learnable synergies", in which the model only selects relevant interactions between data modalities and keeps an "internal memory" of relevant data. Our approach is easily scalable and naturally adapts to multimodal data inputs from clinical routine. We demonstrate this approach on three large multimodal datasets from radiology and ophthalmology and show that it outperforms state-of-the-art models in clinically relevant diagnosis tasks. Our new approach is transferable and will allow the application of multimodal deep learning to a broad set of clinically relevant problems.